Lambar Cas: 54-31-9 Tsarin Halitta: C12H11ClN2O5S
| Matsayin narkewa | 261-263 ° C |
| Yawan yawa | 1.16 (Kyauta) |
| yanayin ajiya | Yanayin rashin aiki, Zazzabin ɗaki 2-8°C |
| narkewa | DMSO:> 5 mg/ml a 60 °C |
| aikin gani | N/A |
| Bayyanar | Kashe-White Solid |
| Tsafta | ≥98% |
An ƙaddamar da Telmisartan a Amurka don maganin hauhawar jini.Ana iya shirya shi a cikin matakai takwas da suka fara da methyl 4-amino-3-methyl benzoate;hawan keke na farko da na biyu zuwa zoben benzimidazole yana faruwa a matakai 4 da 6 bi da bi.Telmisartan yana toshe aikin angiotensin II (Ang II), babban tasirin sakamako na tsarin renin-angiotensin-aldosterone (RAAS).Wannan shine kashi na shida na wannan aji na 《sartans》 da za'a kasuwa bayan sinadarin gubar Losartan.Tasirinsa mai dorewa (rabin-rayuwar awa 24) na iya zama babban bambanci tare da sauran masu adawa da angiotensin II.Ba kamar sauran wakilai da yawa a cikin wannan rukuni ba, aikinsa bai dogara da canzawa zuwa metabolite mai aiki ba, 1-O-acylglucuronide shine babban metabolite da ake samu a cikin mutane.Telmisartan babban abokin adawa ne na masu karɓar AT1 wanda ke daidaita yawancin mahimman tasirin angiotensin II yayin da ba shi da alaƙa ga nau'ikan nau'ikan AT2 ko wasu masu karɓa waɗanda ke da hannu cikin tsarin tsarin zuciya.A cikin karatun asibiti da yawa, Telmisartan, a cikin adadin yau da kullun, yana haifar da tasiri mai dorewa da rage tasirin tasirin jini tare da ƙarancin sakamako masu illa (musamman tari mai alaƙa da magani hade da masu hana ACE a cikin tsofaffi marasa lafiya).
Telmisartan shine antagonist mai karɓar angiotensin II.
