Lambar Cas: 146-56-5 Tsarin Halitta: C20H21ClN2O4
Matsayin narkewa | 176-178 ° C |
Yawan yawa | 1.02 g/cm³ |
yanayin ajiya | yage a yanayin zafi na ɗaki, daga hasken rana kai tsaye kuma a cikin yanayi mai ɗanɗano |
narkewa | 50 mg / ml (a cikin ethanol);Mara narkewa a cikin ruwa |
aikin gani | +111.6 digiri (C=1, methanol) |
Bayyanar | fari ko kusan fari crystalline foda |
Tsafta | ≥97% |
ne "dihydropyridine calcium antagonist" (calcium antagonist, ko jinkirin tashar blocker) wanda ya hana motsi na "calcium ions" zuwa ga jijiyoyin jini santsi Kwayoyin da cardiac myocytes.Bayanan gwaji sun nuna cewa yana da alaƙa da "shafukan ɗaure" don "dihydropyridines" da "marasa dihydropyridines".Dukansu na zuciya da jijiyoyin jini santsin tsoka 'tsarin tafiyar hawainiya' sun dogara ne akan shigar da ''extracellular calcium ions' cikin waɗannan sel ta takamaiman tashoshi na ion.da zaɓe yana hana kwararar ions na calcium a cikin waɗannan membranes tantanin halitta, tsarin da ke shafar ƙwayoyin tsoka mai santsi fiye da ƙwayoyin zuciya.Za'a iya gano tasirin inotropic mara kyau (Inotrope), ko raguwa a cikin kwangilar ƙwayar zuciya, a cikin vitro.Duk da haka, ba a ga irin wannan tasirin a cikin dabbobin da aka gudanar a cikin adadin maganin da aka tsara ba.Matsakaicin adadin calcium na jini ba ya shafar .A cikin kewayon pH na ilimin lissafin jiki, wani fili ne na ionised (pKa = 8.6) wanda hulɗarsa tare da masu karɓar tashar calcium yana da alamar ci gaba da haɓakar haɗin yanar gizon mai karɓa da rarrabuwa, kuma wannan tsarin ci gaba na ci gaba yana haifar da sakamako na gaba.
wani nau'i ne na jijiyoyin bugun jini wanda ke aiki kai tsaye akan tsoka mai santsi na jijiyoyin jini, wanda ke haifar da raguwar juriya na jijiyoyin jini da raguwar hawan jini.Ba a fahimci ainihin hanyar da za a magance angina ba, amma ana tunanin ya haɗa da wadannan: Exertional angina: A cikin marasa lafiya tare da angina exertional, NORVASC yana rage jimlar juriya na gefe (bayan aiki) a lokacin aikin zuciya a kowane matakin motsa jiki kuma yana rage ƙimar. samfurin matsa lamba, don haka rage buƙatar iskar oxygen na myocardial.
Da farko 5mg sau ɗaya kowace rana, yana ƙaruwa zuwa iyakar 10mg sau ɗaya kowace rana.