Lambar Cas: 147403-03-0 Tsarin Halitta: C24H29N5O3
| Matsayin narkewa | 230°C |
| Yawan yawa | 1.41g/cm³ |
| yanayin ajiya | 2-8 ℃ |
| narkewa | Yana kusan rashin narkewa a cikin ruwa, kuma mai narkewa a cikin ethanol shine 5.5 mg / m |
| aikin gani | +76.5 digiri (C=1, ethanol) |
| Bayyanar | fari ko fari-fari, mara wari |
shi ne mara peptide, angiotensin II (AT) antagonist mai karɓa na baka.Yana da babban zaɓi zuwa nau'in mai karɓa na I (AT1) kuma ana iya yin gaba da gaba ba tare da wani tasiri mai motsa rai ba.Hakanan zai iya hana AT1 mai karɓar mai karɓar aldosterol na sakin aldosterol daga ƙwayoyin adrenal glomerular, amma ba shi da wani tasiri mai hanawa akan sakin da aka haifar da potassium, yana nuna tasirin zaɓin sa akan masu karɓar AT1.A cikin vivo gwaje-gwaje a kan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan dabbobin hawan jini sun nuna cewa yana da sakamako mai kyau na antihypertensive kuma ba shi da wani tasiri mai mahimmanci akan aikin kwangilar zuciya da bugun zuciya.Babu tasirin antihypertensive akan dabbobi masu hawan jini na al'ada
Magungunan antihypertensive.antagonist mai karɓar angiotensin II (Ang II) ne wanda ke zaɓin toshe ɗaurin Ang II zuwa masu karɓa na AT1 (tasirinsa na musamman akan masu karɓar AT1 shine kusan sau 20000 fiye da na AT2), ta haka yana hana haɓakar jijiyoyin jini da sakin aldosterone, wanda ya haifar da shi. tasirin hypotensive
Matsakaicin farawa da aka ba da shawarar don allunan shine 80mg (kwayoyin 2), ana sha da baki sau ɗaya a rana.Gabaɗaya, idan ba ta da tasiri don makonni 4, ana iya ƙara adadin zuwa 160mg (kwayoyin 4) sau ɗaya a rana.Dangane da bayanan aikace-aikacen asibiti na ƙasashen waje, matsakaicin adadin zai iya kaiwa 320mg (kwayoyin 8) sau ɗaya a rana
1. Marasa lafiya da hauhawar jini mai rikitarwa tare da ciwon sukari, hauhawar jini mai rikitarwa tare da nephropathy ko ciwon sukari nephropathy mai sauƙi,
2.masu fama da hauhawar jini mai rikitarwa tare da gazawar zuciya ko ciwon zuciya
