Lambar Cas: 330784-47-9 Molecular Formula: C23H26ClN7O3 Fitaccen Hoton

Lambar cas: 330784-47-9 Tsarin kwayoyin halitta: C23H26ClN7O3

Takaitaccen Bayani:

Lambar Cas: 330784-47-9

Sunan Sinadari:

Tsarin kwayoyin halitta: C23H26ClN7O3

Synonyms: (S) -2- (2-Hydroxymethyl-1-pyrrolidinyl) -4- (3-chloro-4-methoxybenzylamino) -5-[(2-pyrimidinylmethyl)carbamoyl] pyrimidine

4-[(3-Chloro-4-methoxybenzyl) amino] -2-[2- (hydroxymethyl) -1-pyrrolidinyl] -N- (2-pyrimidinylmethyl) -5-pyrimidinecarboxamide

Aika mana imel

Cikakken Bayani

Tags samfurin

Ƙayyadaddun samfuran

Matsayin narkewa	150-152 ° C
Yawan yawa	1.372
yanayin ajiya	An rufe shi a bushe, adana a cikin injin daskarewa, ƙasa da -20 ° C
narkewa	DMSO (Dan kadan), methanol (Dan kadan, mai zafi)
aikin gani	N/A
Bayyanar	Fari zuwa Kashe-Fara
Tsafta	≥98%

pharmacodynamics

Ma'aikatar Lafiya ta Koriya ta amince da (Zepeed) don maganin tabarbarewar mazakuta (ED) a watan Agusta 2011. shine mai hanawa nau'in 5 phosphodiesterase (PDE5) mai zaɓi sosai.an ruwaito shine mafi zaɓin mai hana PDE5 akan kasuwa.Farkon Tmax da rabin rayuwa shima ya bambanta tsakanin masu hana PDE5 da aka kasuwa.Sildenafil yana da T_maxa 1 h da rabin rayuwa na 3-5 h.Vardenafil yana da ɗan kama da T_maxna 0.6 h da rabin rayuwa na 4-6 h.Tadalafil yana da rabi mafi tsayi a cikin magungunan da aka sayar da shi tare da rabin rayuwar 17 h.yana da saurin farawa na aiki ya kai T_maxa cikin sa'o'i 0.6 tare da rabin rayuwa na 1.2 h.An kwatanta haɗin (TA-1790) a cikin wallafe-wallafen haƙƙin mallaka.Babban hanyar kawar da ita shine ta bile da najasa.An kuma gano cewa an sake dawowa ta hanyar recirculation na enterohepatic.