Lambar Cetilistat Cas: 282526-98-1 Tsarin Halitta: C25H39NO3
| Matsayin narkewa | 72.0 zuwa 76.0 ° C |
| Yawan yawa | 1.02 |
| yanayin ajiya | An rufe shi a bushe, 2-8 ° C |
| narkewa | Chloroform (Dan kadan), Ethyl Acetate (Dan kadan) |
| aikin gani | N/A |
| Bayyanar | Kashe-farar Cryst |
| Tsafta | ≥98% |
Cetilistat (wanda aka fi sani da ATL-962) an amince da shi a cikin Satumba 2013 ta Ma'aikatar Lafiya, Ma'aikata da Jin Dadin Jafan don kula da kiba, iyakance ga marasa lafiya da ke da nau'in ciwon sukari na 2 (T2DM) da dyslipidemia, kuma tare da tarin jiki. index (BMI) 25 kg/m2duk da jiyya na abinci da / ko aikin motsa jiki.Kamar yadda yake tare da orlistat, cetilistat yana aiki ta hanyar hana lipases na pancreatic a cikin hanji don hana sha mai kuma ta haka yana rage yawan caloric daga abinci.Ba a bayyana shirin sinadarai na magani a cikin wallafe-wallafen kimiyya ba, amma takardar shaidar da ke siffanta cetilistat kuma ta bayyana haɗin analogs tare da bambance-bambancen aryl da wutsiyoyi lipophilic.Haɗin cetilistat ya haɗa da haɗuwa da hexadecylcarbonochloridate tare da 2-amino-5-methylbenzoic acid;sauran analogs an haɗa su ta hanyar bambance-bambancen abubuwan carbonochloride da 2-aminobenzoic acid.Cetilistat mai ƙarfi ne mai hana ɗan adam da lipase pancreatic na bera tare da IC50sna 15 da 136 nM, bi da bi, tare da ƙananan hana trypsin ko chymotrypsin.
Novel pancreatic lipase inhibitor don maganin kiba a duka masu ciwon sukari da marasa ciwon sukari.
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