Lambar Cas: 144701-48-4 Molecular Formula: C33H30N4O2 Fitaccen Hoton

Lambar Cas: 144701-48-4 Tsarin Halitta: C33H30N4O2

Takaitaccen Bayani:

Lambar Cas: 144701-48-4
Sunan Sinadari:
Tsarin kwayoyin halitta: C33H30N4O2

Synonyms: MICARDIS; TU-199; Telmisaran; TIMISHATAN; 2-(4-{[4-Methyl-6-(1-Methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1 ,3-benzodiazol-1-yl]Methyl}phenyl) benzoic acid; 4'[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl) methyl [1,1'-biphenyl] -2-carboxylic acid, BIBR 277; PRITOR; BIBR 277; misartan; BIBR 277SE

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Cikakken Bayani

Tags samfurin

Ƙayyadaddun samfuran

Matsayin narkewa	261-263 ° C
Yawan yawa	1.16 (Kyauta)
yanayin ajiya	Yanayin rashin aiki, Zazzabin ɗaki 2-8°C
narkewa	DMSO:> 5 mg/ml a 60 °C
aikin gani	N/A
Bayyanar	Kashe-White Solid
Tsafta	≥98%

Bayani

an kaddamar da shi a Amurka don maganin hauhawar jini.Ana iya shirya shi a cikin matakai takwas da suka fara da methyl 4-amino-3-methyl benzoate;hawan keke na farko da na biyu zuwa zoben benzimidazole yana faruwa a matakai 4 da 6 bi da bi.yana toshe aikin angiotensin II (Ang II), babban mahimmin sakamako mai tasiri na tsarin renin-angiotensin-aldosterone (RAAS).Wannan shine kashi na shida na wannan aji na 《sartans》 da za'a kasuwa bayan sinadarin gubar Losartan.Tasirinsa mai dorewa (rabin-rayuwar awa 24) na iya zama babban bambanci tare da sauran masu adawa da angiotensin II.Ba kamar sauran wakilai da yawa a cikin wannan rukunin ba, aikinsa bai dogara da canzawa zuwa metabolite mai aiki ba, 1-O-acylglucuronide shine babban metabolite da aka samu a cikin ɗan adam. angiotensin II yayin rashin kusanci ga nau'ikan nau'ikan AT2 ko wasu masu karɓa waɗanda ke cikin tsarin tsarin zuciya.A cikin binciken asibiti da yawa, a cikin adadin yau da kullun sau ɗaya, yana haifar da tasiri mai dorewa da rage tasirin tasirin jini tare da ƙarancin sakamako masu illa (musamman tari mai alaƙa da magani hade da masu hana ACE a cikin tsofaffi marasa lafiya).